Advanced Immunomodulators No Additional Benefit for Inpatient COVID-19 Pneumonia
Advanced Immunomodulators No Additional Benefit for Inpatient COVID-19 Pneumonia
Hospital Too Late for these Drugs--Failure to Correctly Conceptualize the Disease Fatal for the ACTIV-1 IM Trial and Some of its Participants
By Peter A. McCullough, MD, MPH
From the onset of the pandemic, it was clear that COVID-19 was an illness characterized by viral replication, cytokine storm, and micro- and macro-thrombosis. When there was oxygen desaturation and visible “pneumonia” on imaging, that meant cytokine storm was ebbing and blood clotting was occurring in the lungs as shown by autopsy studies.
Because the NIH and big pharma have never been able to conceptualize the illness correctly, they keep striking out in randomized trials. The ACTIV-1 IM protocol randomized patients when it was far too late to one of three advanced immunomodulators (single infusion of abatacept (10 mg/kg; maximum dose, 1000 mg) or infliximab (5 mg/kg) or a 28-day oral course of cenicriviroc (300-mg loading dose followed by 150 mg twice per day) and found no differential improvement in the outcome with mortality for all groups being unacceptably high. In fact, all-cause 28-day mortality was 11.0% for abatacept vs 15.1% for placebo (odds ratio [OR], 0.62 [95% CI, 0.41-0.94]), 13.8% for cenicriviroc vs 11.9% for placebo (OR, 1.18 [95% CI 0.72-1.94]), and 10.1% for infliximab vs 14.5% for placebo (OR, 0.59 [95% CI, 0.39-0.90]).
The lesson learned here is that when the NIH research groups do not recognize how academic physicians have come to understand and treat the disease in the home, there is little chance a hospital protocol such as this would be successful. None of the 52 authors called, sought to discuss, or cited the pathophysiologic figure I published in 2020. This conceptualization guided the world on the principles of treatment and when they should be applied. Academic isolated oblivion, and misguided groupthink is a giant and deadly shortcoming in federally funded COVID-19 research.
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"Because the NIH and big pharma have never been able to conceptualize the illness correctly, they keep striking out in randomized trials." Really? Seriously Dr. McCullough - you actually think that they care about the patients??? They idolize money and power. They don't care about their fellow man - that much is obvious to me after the last three years. Call it what it is - eugenics - see Dr. Denis Rancourt's work - 13+ million people murdered by the shots - or Ed Dowd's - devastating vax injuries still on the rise - TODAY. The idiots (literally) at the FDA and CDC are digging the hole deeper. May they be crushed legally, along with Pfizer and Moderna - who are obvious arms of the government - and be put out of business forever. "Live Not By Lies" - they lie every day. Now the world ( and the criminals ) are aware that the shots were a bait-and-switch - see Kevin McKernan's work - and highly contaminated with plasmid DNA. NO ONE is stopping the shots. Does that make sense? Put your faith and trust in Jesus Christ - nothing else matters. Peace.
You assume they WANT to improve patient outcomes.