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Post-COVID Syndrome Associated with Persistent Spike Protein

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Post-COVID Syndrome Associated with Persistent Spike Protein

Free and Vesicular Spike in the Blood May Explain Persistent Symptoms after Hospitalization

Peter A. McCullough, MD, MPH™
Mar 13
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Post-COVID Syndrome Associated with Persistent Spike Protein

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By Peter A. McCullough, MD, MPH

Approximately half of patients hospitalized mainly in 2020 and 2021 with acute COVID-19 had post-COVID symptoms for weeks afterward. Craddock et al measured both viral RNA and Spike protein in 116 patients hospitalized with COVID-19 at the University of Kansas. Follow-up was not standardized and had most at 8-12 weeks and some out to 24 weeks with information (PASC=post-COVID symptoms).

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Craddock V, Mahajan A, Spikes L, Krishnamachary B, Ram AK, Kumar A, Chen L, Chalise P, Dhillon NK. Persistent circulation of soluble and extracellular vesicle-linked Spike protein in individuals with postacute sequelae of COVID-19. J Med Virol. 2023 Feb;95(2):e28568. doi: 10.1002/jmv.28568. PMID: 36756925.

They found that measurement of viral RNA and Spike protein was valuable in describing a relationship between the presence of post-COVID symptoms (fatigue, lethargy, etc.) and persistent Spike both free and circulating in vesicular particles. The amount of Spike was most strongly correlated with 1) severity of symptoms in the hospital, 2) duration of hospitalization, and 3) blood d-dimer level.

This study points to the pressing clinical need for the US FDA to grant in vitro diagnostics companies approvals to market blood assays for Spike protein and hopefully both viral and vaccine RNA and mRNA. In the meantime, there is now support to measure d-dimer in post COVID patients as weak surrogate of circulating Spike.

It is reassuring to patients suffering with post-COVID or “long-COVID” that it is not all in their heads, the pathophysiology is pointing to persistence of Spike protein in the blood which is pathogenic and likely driving tissue/organ injury with associated symptoms.

Because COVID-19 mRNA vaccines further load the body with genetic code and more Spike protein, it is likely that vaccination worsens post-COVID syndromes despite raising antibodies against the Spike protein. I have not found claims that vaccination reduces long-COVID syndromes valid in bias papers that are pushing vaccines.

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Craddock V, Mahajan A, Spikes L, Krishnamachary B, Ram AK, Kumar A, Chen L, Chalise P, Dhillon NK. Persistent circulation of soluble and extracellular vesicle-linked Spike protein in individuals with postacute sequelae of COVID-19. J Med Virol. 2023 Feb;95(2):e28568. doi: 10.1002/jmv.28568. PMID: 36756925.

Courageous Discourse™ with Dr. Peter McCullough & John Leake is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.

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Post-COVID Syndrome Associated with Persistent Spike Protein

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22 Comments
Inisfad
Mar 13

While the medical research may point to the amount of spike proteins circulating that might cause the symptoms of ‘long covid’, try finding a doctor or hospital that will actually check this in order to confirm your symptoms. I suspect it will be virtually impossible, sadly.

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doors
Mar 13

I’m hoping Fauci and his gang ultimately stand trial for crimes against humanity. Not only for being responsible for the funding of this bioweapon in violation of Obama’s order to stop GOF but for lying about the efficacy of safe affordable early treatment. The untold death and suffering of millions worldwide is incalculable. And yes those in my social circle are starting to witness people dying suddenly. It’s becoming more impossible for people to dismiss. Thank God there are ways to treat long haul. My doctor advised me and my family to continue to take ivermectin for six weeks after the 5 day treatmrnt to avoid long haul. We took it twice a week.

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