I'm still confused by shedding. What is being shed — spike protein, or the mRNA that programs cells to produce spike protein? If the former, how can it be in high enough volumes to cause problems; wouldn't the immune system deal with it the same as it would any slight COVID-19 exposure? Or does the pseudouridine alteration change this be…
I'm still confused by shedding. What is being shed — spike protein, or the mRNA that programs cells to produce spike protein? If the former, how can it be in high enough volumes to cause problems; wouldn't the immune system deal with it the same as it would any slight COVID-19 exposure? Or does the pseudouridine alteration change this behavior (intact Covid virus does not have the pseudouridine alteration, I don't think)?
If the latter (shedding lipid nanoparticles), that would make a little more sense, but I'd like more clarification on the mechanism. As I understand it, the whole point of the lipid nanoparticles was to keep the mRNA intact long enough to make it into the target cells. Do the shed exosomes contain the mRNA within lipid nanoparticles?
Yes, I know there are innumerable articles about shedding and I need to do some reading. But these are the questions that occur to me whenever I hear about shedding.
Yes, both spike protein (short term problem) & MmRNA--unnaturally long lasting mRNA--long term problem. The pseudouridine is resistant to enzymatic breakdown & lasts days to weeks to ..., whereas natural mRNA lasts minutes to hours, days @ most, IIRC.
I'm still confused by shedding. What is being shed — spike protein, or the mRNA that programs cells to produce spike protein? If the former, how can it be in high enough volumes to cause problems; wouldn't the immune system deal with it the same as it would any slight COVID-19 exposure? Or does the pseudouridine alteration change this behavior (intact Covid virus does not have the pseudouridine alteration, I don't think)?
If the latter (shedding lipid nanoparticles), that would make a little more sense, but I'd like more clarification on the mechanism. As I understand it, the whole point of the lipid nanoparticles was to keep the mRNA intact long enough to make it into the target cells. Do the shed exosomes contain the mRNA within lipid nanoparticles?
Yes, I know there are innumerable articles about shedding and I need to do some reading. But these are the questions that occur to me whenever I hear about shedding.
Yes, both spike protein (short term problem) & MmRNA--unnaturally long lasting mRNA--long term problem. The pseudouridine is resistant to enzymatic breakdown & lasts days to weeks to ..., whereas natural mRNA lasts minutes to hours, days @ most, IIRC.
Short answer - nobody knows. Worse, the people we pay to care, don't.