Worsened Menstrual Symptoms for Endometriosis Patients after COVID-19 Vaccination
Changes in Bleeding Prominent Among Those Not on Hormonal Therapy
By Peter A. McCullough, MD, MPH
Endometriosis is a disease in which tissue similar to the lining of the uterus grows outside the uterus. It can cause severe pain in the pelvis and make it harder to get pregnant. Endometriosis can start at a person's first menstrual period and last until menopause.
Hormonal therapies used to treat endometriosis include:
Hormonal contraceptives. Birth control pills, shots, patches and vaginal rings
Danazol. A is a synthetic steroid derived from ethisterone, an androgen similar to testosterone.
Gonadotropin-releasing hormone (Gn-RH) agonists and antagonists. These medicines block the menstrual cycle and lower estrogen levels. This causes endometriosis tissue to shrink.
Progestin therapy. Progestin therapies include a tiny device placed in the uterus that releases levonorgestrel (Mirena, Skyla, others), a contraceptive rod placed under the skin of the arm (Nexplanon), birth control shots (Depo-Provera) or a progestin-only birth control pill (Camila, Slynd).
Aromatase inhibitors. The aromatase inhibitors used for endometriosis include letrozole and anastrozole.
Martínez-Zamora et al, evaluated patients with and without endometriosis with the first and second injections of mRNA COVID-19 vaccines (Pfizer or Moderna). As with many studies, the majority had changes in their menstrual cycle. The interesting observation was that those NOT on hormonal therapy had more bleeding and other symptoms. Thus treatment for endometriosis appeared to lessen the impact.
Vaccinations of any type should not cause misery for women who suffering from endometriosis. This paper is important since I plan to advise the occasional patient who may be forced into vaccination to expect a rough ride of they are not on hormonal therapy.
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Peter A. McCullough, MD, MPH
President, McCullough Foundation
I appreciate how passionate and meticulous you are with keeping up with and applying the most current research to your patients, and for sharing with other doctors who wish to do the same. I don't know how you carve out time for all of this reading and writing, but your dedication is awe-inspiring and life-saving. Thank you for efforts.
All vaccination should be halted.