Direct Cardiac Effects of mRNA-Based SARS-CoV-2 Vaccines
Isolated Cardiomyocyte Study Finds Dysfunction within 48 Hours
By Peter A. McCullough, MD, MPH
There have been many drugs that have never made it on the market because they cause heart rhythm disturbances. Because the COVID-19 vaccines were rushed in development, preclinical cardiac toxicity studies were skipped. Now three years into the disastrous COVID-19 vaccine campaign, we are learning that probably every person sustains some degree of heart dysfunction or damage within 48 hours of the shot.
Schreckenberg et al studied the direct effect of administering Pfizer and Moderna mRNA to isolated adult rat cardiomyocytes. The results were not good.
“After 48 h, expression of the encoded spike protein was detected in ventricular cardiomyocytes for both mRNAs. At this point in time, mRNA-1273 induced arrhythmic as well as completely irregular contractions associated with irregular as well as localized calcium transients, which provide indications of significant dysfunction of the cardiac ryanodine receptor (RyR2). In contrast, BNT162b2 increased cardiomyocyte contraction via significantly increased protein kinase A (PKA) activity at the cellular level.
Here we demonstrated for the first time, that in isolated cardiomyocytes, both mRNA-1273 and BNT162b2 induce specific dysfunctions that correlate pathophysiologically to cardiomyopathy. Both RyR2 impairment and sustained PKA activation may significantly increase the risk of acute cardiac events.”
This means that mRNA coding for foreign protein is taken up by heart cells and it makes them sick with abnormalities of contraction and electrical conduction. It implies that COVID-19 vaccines could cause a cardiac arrhythmia and cardiac arrest in the absence of myocarditis. This is very bad news for all mRNA products. If heart muscle cells cannot be excluded from biodistribution of mRNA, this means every new mRNA vaccine could cause heart problems including cardiac arrest.
This and many studies support a complete moratorium on mRNA research given these very serious findings. I called for that moratorium on a national interview in August, 2023.
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Peter A. McCullough, MD, MPH
President, McCullough Foundation
Schreckenberg R, Woitasky N, Itani N, Czech L, Ferdinandy P, Schulz R. Cardiac side effects of RNA-based SARS-CoV-2 vaccines: Hidden cardiotoxic effects of mRNA-1273 and BNT162b2 on ventricular myocyte function and structure. Br J Pharmacol. 2023 Oct 12. doi: 10.1111/bph.16262. Epub ahead of print. PMID: 37828636.