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Multi-Hit Hypothesis for the Oncogenic Potential of mRNA COVID-19 Vaccines
Pathophysiologic Support for the Observation of "Turbo Cancer" after Vaccination
By Peter A. McCullough, MD, MPH
As an internist and specialist, it is hard for me to believe that a novel biologic product could cause heart, neurologic, thrombotic, and immunologic disease but to make matters even worse, could also play a role in the initiation and acceleration of oncogenesis. In Western countries before the pandemic, the leading causes of death were heart disease 40%, cancer 40%, and death from other known causes (homicide, suicide, accidents, etc). The mRNA COVID-19 vaccines if proven to promote cancer, would then be implicated in rises in all-cause mortality being observed world wide.
In 1984, Sutherland and Bailer proposed the “Multi-Hit Hypothesis of Carcinogenesis:”
“A new multihit model of carcinogenesis is developed for use in evaluating age-specific cancer incidence rates in human populations. The model allows for some heterogeneity in both risk (perhaps genetic) and pathway (number of hits).”
They essentially said it takes multiple different hits or insults to cells and their genetic machinery to cause a normal cell to become cancerous. Forty years later, Sutherland and Bailer could not have dreamed about the application of their hypothesis to global mass genetic vaccination given every six months to a broad population, some with high risks for, or even with incipient cancer.
Angues and Bustos just released a paper on the Authorea preprint server that assemblies the evidence to date that both mRNA and the Spike protein work within human cells to cause changes that result in oncogenesis. The figure shown is consistent with a multi-hit hypothesis of oncogenesis after injection with Pfizer or Moderna.
Many questions remain including cumulative dose effect, predisposition (e.g. loss of function mutations in BRCA1/2 P53), additional exposures such as UV radiation, smoking, alcohol, and finally catabolism of mRNA and Spike. Undoubtedly decades of research will be needed to fully understand COVID-19 vaccination and cancer. As we point out in our book Courage to Face COVID-19, it took over 40 years from when Sir Austin Bradford Hill causally associated smoking with lung cancer until there was capitulation by the medical orthodoxy. Let’s hope the world wide exposure of mRNA and alacrity of modern research can shorten this timeframe.
Here are some reasonable first steps:
Remove all COVID-19 vaccines from human use to reduce any additional exposure
CDC should link vaccine administration data with all government cancer registries
The National Cancer Institute should urgently fund mRNA COVID-19 vaccine cancer research
Vaccinated with prior histories of cancer should make a specific post-vaccination oncology clinic visit to consider reassessment or restaging
Vaccinated with no prior history of malignancy should check to see they are up to date on routine cancer screening (prostate, lung, breast, ovary, uterus, colon).
All vaccinated patients and their doctors should be alert to any change in health status and have a low threshold for clinical investigation
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Peter A. McCullough, MD, MPH
President, McCullough Foundation